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What is Histidine?

Histidine is an amino acid essential for the human body.

Amino acids are the building blocks of proteins. Most proteins in the human body are composed of 21 amino acids.

Why do we need histidine?

Histidine contributes to many bodily functions, including:

Protein synthesis

Histidine promotes protein synthesis and turnover.

Skin health

Histidine is found in high concentration in a skin barrier protein called filaggrin that help protect against UV radiations (1).

Immune responses

Histidine is needed by our body to produce histamine which is a molecule involved in local immune responses.

Recommended Daily Allowance for histidine

Recommended Daily Allowance for a 44-year-old male moderately active, weighting 70 kg and 175 cm tall is 1.6 g (2).

Do you want to know your personal recommendations ?

The FNB (Food and Nutrition Board of the Institute of Medicine) set its recommendations for histidine at 18 mg per gram of proteins (3).

They also recommend that proteins intake for most people should be between 10 % and 30 % of total Calories. This is called the “adequate macronutrient distribution range” (AMDR) and is based on decreasing risk of chronic disease and providing adequate intake of other nutrients.

In our app, the default value is set at 15 % of total calories, which is inside the AMDR and bases on complementing the values for carbohydrates and fats.

To get your histidine recommendation expressed in gram, we combine the above two recommendations.

What are the risks of too much histidine?

The FNB did not establish an upper limit because adequate data from human or animal studies were lacking. This does not mean that there is no potential for adverse effects resulting from high intakes of histidine from dietary supplements. Since data are limited, caution may be warranted.

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